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Clobetasol is a medicine that’s used on the skin to treat swelling, itching and irritation. It can help with skin problems such as: eczema, including contact dermatitis, psoriasis, lichen planus, lupus. Clobetasol should not be used by patients who; have ever had an allergic reaction to clobetasol, or to cetostearyl alcohol or chlorocresol (ingredients in clobetasol cream), have ever had an allergic reaction to any other medicine in the past, have a skin infection, broken skin, cuts or itchy skin which isn’t inflamed or red. If you have a skin infection, using clobetasol can make it worse or cause it to spread.